Chromosome localization

Across TCGA cell cohorts, RNA activity of the Chromosome localization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C16orf95, SS18, and TSEN15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C16orf95 grouped by Chromosome localization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C16orf95 →	-0.779	-0.201	<.001	<.001	3	5
PANCREAS	SS18 →	-0.987	-0.194	<.001	.004	3	5
LUNG_NSCLC_LUSC	TSEN15 →	-1.151	-0.238	.003	.007	3	4
CNS	RBBP7 →	-0.457	-0.158	.002	.003	3	4
OVARY	EXTL2 →	-1.396	-0.168	.002	.005	3	4
BLOOD_Lymphoma	RPRD1A →	-0.868	-0.317	.003	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C16orf95 by Chromosome localization activity — LARGE_INTESTINE

Explore this box plot interactively →