Chromosome localization

Across TCGA cell cohorts, RNA activity of the Chromosome localization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NBPF1, UBE2S, and HCN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chromosome localization activity versus NBPF1 in LUNG_NSCLC_LUAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NBPF1 →	+0.676	+0.107	.003	.006	3	5
BLOOD_Lymphoma	UBE2S →	+0.787	+0.130	.008	.007	3	5
LUNG_NSCLC_LUAD	HCN3 →	+0.715	+0.113	.001	.007	3	5
LUNG_NSCLC_LUSC	SH3GLB2 →	+1.157	+0.184	.001	.003	3	4
KIDNEY	TAP1 →	-1.907	-0.349	<.001	<.001	3	4
BLOOD_Leukemia	COTL1 →	-1.942	-0.108	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050000 vs NBPF1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →