Peripheral nervous system neuron differentiation

Across TCGA patient cohorts, RNA activity of the Peripheral nervous system neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KNOP1, RPS5, and SARM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system neuron differentiation activity versus KNOP1 in BRCA (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KNOP1 →	-0.349	-0.041	.002	.006	3	5
OV	RPS5 →	-0.199	-0.038	.002	<.001	3	5
UCEC	SARM1 →	+0.529	+0.074	<.001	.006	3	5
OV	C1S →	+0.491	+0.053	.004	<.001	3	5
BRCA	DCN →	+0.822	+0.039	<.001	.008	3	5
BRCA	DDX21_S71 →	-1.131	-0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048934 vs KNOP1 — BRCA

Explore this scatter interactively →