Peripheral nervous system neuron differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Peripheral nervous system neuron differentiation pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Peripheral nervous system neuron differentiation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and LUSC, show the opposite pattern, with higher activity associated with better survival.

LGG, LUSC, and DLBC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.571	0.343	<.001	47	view →
LUSC	DFS	Quartile	II,III,IV	0.732	0.217	.003	39	view →
DLBC	DFS	Median	II,III,IV	0.190	0.864	.001	26	view →
BRCA	OS	Tertile	III,IV	0.930	0.786	.001	26	view →
LIHC	OS	Quartile	II,III,IV	0.492	0.751	.006	20	view →
ESCA	OS	Median	All	0.787	0.620	.005	20	view →
COAD	DFS	Quartile	IV	0.300	0.679	.005	17	view →
LUAD	DFS	Quartile	All	0.385	0.301	.009	17	view →
THYM	OS	Median	II,III,IV	0.729	0.976	.018	12	view →
THCA	DFS	Median	All	0.764	0.921	.002	11	view →
OV	DFS	Quartile	IV	0.659	0.302	.023	8	view →
CESC	DFS	Median	II,III,IV	0.705	0.841	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0048934–LGG (OS)

Open the LGG breakdown →