Peripheral nervous system neuron differentiation

Across TCGA patient cohorts, RNA activity of the Peripheral nervous system neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADH1B, HOOK1, and HPGDS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system neuron differentiation activity versus ADH1B in UCEC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADH1B →	+1.094	+0.248	<.001	<.001	3	5
BRCA	HOOK1 →	-0.754	-0.584	.005	.006	3	5
HNSC	HPGDS →	+0.855	+0.619	<.001	.004	3	4
UCEC	PRMT5 →	-0.535	-0.344	.003	<.001	3	4
PDAC	POLA1 →	-0.189	-0.723	.008	.006	3	4
HNSC	CHRDL1 →	+1.491	+0.732	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048934 vs ADH1B — UCEC

Explore this scatter interactively →