Peripheral nervous system neuron differentiation

Across TCGA patient cohorts, RNA activity of the Peripheral nervous system neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOP2, RPS2, and SYNJ1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system neuron differentiation activity versus NOP2 in GBM (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NOP2 →	-0.401	-0.357	<.001	<.001	3	5
GBM	RPS2 →	-0.257	-0.426	<.001	<.001	3	4
OV	SYNJ1 →	+0.831	+1.589	<.001	<.001	3	4
GBM	VPS39 →	+0.137	+0.245	<.001	<.001	3	4
GBM	WDR36 →	-0.235	-0.271	<.001	<.001	3	4
UCEC	WDR43_S77 →	-0.544	-0.324	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048934 vs NOP2 — GBM

Explore this scatter interactively →