Peripheral nervous system neuron differentiation

Across TCGA cell cohorts, RNA activity of the Peripheral nervous system neuron differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLXNA2, GBX2, and FAAH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLXNA2 grouped by Peripheral nervous system neuron differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PLXNA2 →	+0.154	+0.961	.003	.006	3	5
BLOOD_Myeloma	GBX2 →	-0.278	-0.171	.004	.003	3	4
OVARY	FAAH →	+0.236	+1.290	.001	.001	3	4
OVARY	DYRK1A →	-0.263	-1.042	.004	.009	2	5
LUNG_NSCLC_LUAD	ANKRD40 →	+0.152	+0.828	<.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	DPEP1 →	-0.200	-1.547	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLXNA2 by Peripheral nervous system neuron differentiation activity — OVARY

Explore this box plot interactively →