Stem cell fate commitment

Across TCGA cell cohorts, RNA activity of the Stem cell fate commitment pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHCTF1, CYP2W1, and PPP1R12A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AHCTF1 grouped by Stem cell fate commitment-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AHCTF1 →	-0.272	-1.339	.002	.005	3	4
SOFT_TISSUE	CYP2W1 →	-0.161	-1.183	.004	.007	3	4
CNS	PPP1R12A →	+0.386	+1.282	.007	<.001	3	4
BLOOD_Myeloma	CELF6 →	+0.181	+0.139	.003	.002	3	3
BLOOD_Leukemia	MMP19 →	+0.293	+0.133	<.001	.002	3	3
BLOOD_Leukemia	NAT10 →	-0.284	-0.180	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AHCTF1 by Stem cell fate commitment activity — SOFT_TISSUE

Explore this box plot interactively →