Stem cell development

Across TCGA patient cohorts, RNA activity of the Stem cell development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD248, COL1A2, and GSN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stem cell development activity versus CD248 in OV (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD248 →	+0.601	+0.037	<.001	<.001	3	8
GBM	COL1A2 →	+0.678	+0.026	.002	.001	3	8
OV	GSN →	+0.663	+0.041	<.001	<.001	3	8
OV	PCOLCE →	+0.659	+0.029	<.001	<.001	3	8
PDAC	PPM1F →	+0.280	+0.032	<.001	<.001	3	8
CCRCC	HPGDS →	+0.487	+0.025	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048864 vs CD248 — OV

Explore this scatter interactively →