Stem cell development

Across TCGA patient cohorts, RNA activity of the Stem cell development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MASTL_S453, RFFL_S226, and ATRX_S784, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stem cell development activity versus MASTL_S453 in OV (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MASTL_S453 →	+1.296	+0.227	<.001	<.001	3	3
OV	RFFL_S226 →	-1.869	-0.434	.003	<.001	3	2
OV	ATRX_S784 →	+1.303	+0.277	.003	<.001	3	2
COAD	CLASP1_S572 →	+1.367	+0.257	<.001	<.001	3	2
OV	DOCK6_S1308 →	-1.045	-0.161	<.001	<.001	3	2
COAD	DTNB_T534 →	+0.782	+0.232	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048864 vs MASTL_S453 — OV

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