Hair follicle maturation

pathway activity — cross-omics
GO:0048820Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Hair follicle maturation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB2, SASH3, and LSP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECTGFB2 →+0.654+0.084<.001<.00137
LSCCSASH3 →-0.451-0.078<.001<.00135
OVLSP1 →-0.407-0.051.007.00326
OVMACROH2A2 →+0.440+0.043<.001.00535
LUADTSPAN6 →+0.466+0.056<.001<.00135
LSCCADA2 →-0.575-0.071<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration