Positive regulation of hair follicle maturation

Across TCGA patient cohorts, RNA activity of the Positive regulation of hair follicle maturation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT5A, MSX2, and CXCL14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hair follicle maturation activity versus WNT5A in OV (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WNT5A →	+1.509	+0.285	.002	.002	3	5
UCEC	MSX2 →	+2.330	+0.839	<.001	<.001	3	4
UCEC	CXCL14 →	+1.633	+0.717	.004	.001	3	4
UCEC	RN7SKP240 →	+0.782	+0.608	.005	.005	3	4
UCEC	RUNX2-AS1 →	+0.602	+0.503	<.001	.004	3	4
OV	LINC01399 →	-0.846	-0.258	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048818 vs WNT5A — OV

Explore this scatter interactively →