Regulation of dendrite morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of dendrite morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSPH9, STAP2, and NFKB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RSPH9 grouped by Regulation of dendrite morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RSPH9 →	+0.298	+0.825	.004	.009	3	3
LUNG_NSCLC_LUAD	STAP2 →	-1.827	-0.168	.002	.006	2	4
URINARY_TRACT	NFKB2 →	+1.517	+0.306	.007	.007	2	3
OVARY	RABGGTA →	-0.871	-0.791	.005	.009	3	2
OVARY	CRY2 →	-0.504	-0.480	.007	.004	3	2
PANCREAS	CUZD1 →	+0.451	+0.186	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RSPH9 by Regulation of dendrite morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →