Dendrite morphogenesis

Across TCGA patient cohorts, RNA activity of the Dendrite morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SESTD1, PSMB10_S230, and RPL5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendrite morphogenesis activity versus SESTD1 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SESTD1 →	+0.400	+0.062	<.001	<.001	3	7
GBM	PSMB10_S230 →	-0.641	-0.044	<.001	.001	3	6
GBM	RPL5 →	-0.213	-0.057	<.001	<.001	3	6
PDAC	SEPTIN11 →	+0.287	+0.022	.002	.005	2	7
GBM	SET_S7 →	-0.445	-0.065	<.001	<.001	3	6
PDAC	B3GLCT →	+0.362	+0.027	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048813 vs SESTD1 — GBM

Explore this scatter interactively →