Genitalia development

Across TCGA patient cohorts, RNA activity of the Genitalia development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSG1, RPL17P25, and UPP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Genitalia development activity versus GSG1 in LSCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GSG1 →	+0.295	+0.315	<.001	.009	3	4
COAD	RPL17P25 →	+0.129	+0.573	<.001	<.001	3	4
BRCA	UPP1 →	-0.805	-0.633	<.001	.006	3	4
LUAD	TNNT1 →	-1.414	-0.166	.008	.006	2	4
HNSC	MLIP →	-0.640	-0.583	.005	.003	3	3
BRCA	MLKL →	-0.530	-0.775	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048806 vs GSG1 — LSCC

Explore this scatter interactively →