Pronephros development

Across TCGA cell cohorts, RNA activity of the Pronephros development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD3, RGS9BP, and STN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMAD3 grouped by Pronephros development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SMAD3 →	+1.511	+1.507	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RGS9BP →	+0.133	+1.446	<.001	.009	3	3
LUNG_NSCLC_LUSC	STN1 →	+1.400	+1.909	<.001	.002	3	3
OESOPHAGUS	KDELR3 →	+1.459	+1.233	.002	.005	3	3
OESOPHAGUS	OLFM2 →	+2.132	+1.198	.005	.007	3	3
OESOPHAGUS	DNAJB5 →	+1.471	+1.730	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMAD3 by Pronephros development activity — OVARY

Explore this box plot interactively →