Calcium ion-regulated exocytosis of neurotransmitter

Across TCGA patient cohorts, RNA activity of the Calcium ion-regulated exocytosis of neurotransmitter pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSS1, CACNA1D, and DEGS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion-regulated exocytosis of neurotransmitter activity versus ACSS1 in GBM (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ACSS1 →	+0.614	+0.926	.001	<.001	3	4
BRCA	CACNA1D →	+0.969	+0.381	<.001	.001	3	4
BRCA	DEGS2 →	+1.475	+0.328	<.001	.001	3	4
GBM	UPP1 →	-0.911	-1.171	<.001	<.001	3	4
UCEC	NTRK3 →	+0.401	+0.567	.005	.008	3	4
BRCA	HJURP →	-0.858	-0.327	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048791 vs ACSS1 — GBM

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