Mesenchymal cell differentiation

Across TCGA patient cohorts, RNA activity of the Mesenchymal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF157, CYP4F22, and FAM86B3P, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal cell differentiation activity versus ZNF157 in COAD (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZNF157 →	-0.065	-2.724	.005	.001	2	1
COAD	CYP4F22 →	-0.143	-2.706	.009	<.001	2	1
COAD	FAM86B3P →	-0.530	-2.706	.005	<.001	2	1
COAD	NPIPB9 →	-0.176	-2.706	.008	<.001	2	1
COAD	RNU5B-4P →	-1.055	-2.724	<.001	.001	2	1
COAD	SNORA69 →	-0.573	-2.706	.003	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048762 vs ZNF157 — COAD

Explore this scatter interactively →