Smooth muscle tissue development

Across TCGA cell cohorts, RNA activity of the Smooth muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STT3B, MRPL24, and PRUNE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle tissue development activity versus STT3B in SOFT_TISSUE (Pearson r = -0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	STT3B →	-0.940	-1.769	<.001	<.001	3	4
BLOOD_Leukemia	MRPL24 →	-0.807	-1.005	<.001	.007	3	4
BLOOD_Leukemia	PRUNE1 →	-0.805	-1.290	<.001	<.001	3	4
OVARY	AP4M1 →	+1.226	+2.030	.008	<.001	3	4
BONE	STOM →	+2.356	+1.443	.002	<.001	3	3
LIVER	ENDOV →	+1.886	+1.846	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048745 vs STT3B — SOFT_TISSUE

Explore this scatter interactively →