Positive regulation of skeletal muscle fiber development

Across TCGA cell cohorts, RNA activity of the Positive regulation of skeletal muscle fiber development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHOX2, SH2D3A, and CDH1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of skeletal muscle fiber development activity versus SHOX2 in URINARY_TRACT (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SHOX2 →	+2.752	+1.605	<.001	<.001	3	20
URINARY_TRACT	SH2D3A →	-2.736	-1.209	<.001	.001	3	11
URINARY_TRACT	CDH1 →	-4.227	-1.181	<.001	.001	3	10
URINARY_TRACT	DZIP1L →	+1.421	+1.118	<.001	.003	3	9
URINARY_TRACT	SYTL1 →	-2.436	-1.221	.001	.001	3	9
STOMACH	ZEB1 →	+2.622	+1.427	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048743 vs SHOX2 — URINARY_TRACT

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