Regulation of skeletal muscle fiber development

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle fiber development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO22, SHOX2, and WDR61, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle fiber development activity versus FBXO22 in SOFT_TISSUE (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FBXO22 →	+0.797	+0.222	.001	<.001	3	15
URINARY_TRACT	SHOX2 →	-1.741	-0.185	.001	.005	3	11
LUNG_SCLC	WDR61 →	+0.468	+0.108	<.001	.004	3	9
BREAST	PLIN3 →	-0.926	-0.178	.002	.004	3	8
LIVER	NIBAN1 →	-2.186	-0.225	.002	<.001	3	8
SOFT_TISSUE	TGFBI →	-3.324	-0.178	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048742 vs FBXO22 — SOFT_TISSUE

Explore this scatter interactively →