Epidermis morphogenesis

Across TCGA cell cohorts, RNA activity of the Epidermis morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIX1, USP20, and CRNKL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIX1 grouped by Epidermis morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SIX1 →	-1.742	-1.089	<.001	.001	3	4
PANCREAS	USP20 →	-1.059	-1.396	<.001	<.001	3	4
LIVER	CRNKL1 →	-0.516	-1.341	.001	.002	3	4
KIDNEY	IFNGR1 →	+0.806	+1.030	.001	.005	3	4
OVARY	DNAH11 →	-0.914	-0.978	.007	.002	3	3
LUNG_NSCLC_LUAD	AKNA →	-0.708	-0.973	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIX1 by Epidermis morphogenesis activity — BREAST

Explore this box plot interactively →