Negative regulation of astrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of astrocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK9_S927, EFEMP1, and LIMS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of astrocyte differentiation activity versus DOCK9_S927 in COAD (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DOCK9_S927 →	+0.404	+0.043	.006	.003	3	5
COAD	EFEMP1 →	+0.617	+0.062	.001	<.001	3	5
OV	LIMS1 →	+0.529	+0.083	.004	.005	3	4
BRCA	FERMT2 →	+0.513	+0.063	.001	<.001	3	4
HNSC	VCL_S272 →	+0.575	+0.076	<.001	<.001	3	4
BRCA	TRMT1L →	-0.227	-0.049	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048712 vs DOCK9_S927 — COAD

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