Negative regulation of astrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of astrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARPC5L, CDKN1B, and DNAJC18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of astrocyte differentiation activity versus ARPC5L in HNSC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARPC5L →	-0.542	-0.645	<.001	.001	3	4
GBM	CDKN1B →	+0.311	+0.175	.003	.001	3	3
HNSC	DNAJC18 →	+0.348	+0.507	.007	.005	2	4
LSCC	RPL21P134 →	+0.275	+0.582	<.001	<.001	3	3
GBM	RPL22P24 →	+0.444	+0.162	<.001	.002	3	3
GBM	RPL39P29 →	+1.279	+0.176	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048712 vs ARPC5L — HNSC

Explore this scatter interactively →