Positive regulation of astrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of astrocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLA, USP7, and NCR1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GLA grouped by Positive regulation of astrocyte differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GLA →	+0.348	+1.552	<.001	.004	3	2
SKIN	USP7 →	+0.680	+1.697	.003	.003	3	2
SKIN	NCR1 →	+0.605	+2.107	.007	.003	2	3
SKIN	PPP2CA →	+0.439	+2.002	.002	.006	3	2
SKIN	AKR1D1 →	+0.183	+1.930	<.001	.005	3	2
SKIN	MDM2 →	+1.265	+1.930	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GLA by Positive regulation of astrocyte differentiation activity — CNS

Explore this box plot interactively →