Positive regulation of astrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of astrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC5A9, ZCCHC17, and FOSB, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of astrocyte differentiation activity versus SLC5A9 in SKIN (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC5A9 →	+1.066	+2.262	.005	<.001	3	2
SKIN	ZCCHC17 →	+0.603	+1.874	.004	<.001	3	2
SKIN	FOSB →	+4.016	+2.057	.004	<.001	3	2
SKIN	CPM →	+2.370	+1.722	.004	.001	3	2
CNS	IGFBP3 →	+5.840	+1.909	.002	<.001	3	2
SKIN	EME1 →	-1.456	-2.188	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048711 vs SLC5A9 — SKIN

Explore this scatter interactively →