Oligodendrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Oligodendrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBNL, HLA-B, and NDUFC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligodendrocyte differentiation activity versus DBNL in OESOPHAGUS (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DBNL →	-0.724	-0.758	.004	.005	3	5
LUNG_NSCLC_LUAD	HLA-B →	-2.156	-0.781	.003	.002	3	4
URINARY_TRACT	NDUFC1 →	-0.687	-1.028	.007	.004	3	4
OESOPHAGUS	DNAJC7 →	-0.715	-1.097	.004	.005	3	4
STOMACH	ZDHHC9 →	+1.037	+0.333	.001	.001	2	4
BLOOD_Lymphoma	AGR2 →	+0.506	+0.231	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048709 vs DBNL — OESOPHAGUS

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