Astrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Astrocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXW7, RIMS3, and PEMT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXW7 grouped by Astrocyte differentiation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FBXW7 →	-0.439	-0.085	.004	.007	3	4
BLOOD_Lymphoma	RIMS3 →	+0.265	+0.117	.001	<.001	3	4
BLOOD_Lymphoma	PEMT →	-0.343	-0.089	<.001	.003	3	4
BLOOD_Leukemia	H2AZ1 →	-0.229	-0.078	<.001	<.001	3	4
BREAST	MRPS5 →	-0.298	-0.091	.002	.004	3	4
UPPER_AERODIGESTIVE_TRACT	DOCK4 →	-0.122	-0.111	.004	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXW7 by Astrocyte differentiation activity — BLOOD_Lymphoma

Explore this box plot interactively →