Embryonic skeletal system development

Across TCGA patient cohorts, RNA activity of the Embryonic skeletal system development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NIPBL_T735, STAMBPL1, and BIN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic skeletal system development activity versus NIPBL_T735 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NIPBL_T735 →	+0.804	+0.447	<.001	.002	2	6
GBM	STAMBPL1 →	-0.352	-0.509	<.001	<.001	3	4
HNSC	BIN1 →	-1.180	-0.412	<.001	<.001	3	4
BRCA	CHD3 →	+0.463	+0.550	<.001	<.001	2	5
UCEC	ABI2_S227 →	+0.597	+0.340	<.001	.002	3	4
HNSC	KIF7 →	+0.775	+0.464	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048706 vs NIPBL_T735 — BRCA

Explore this scatter interactively →