Embryonic skeletal system development

Across TCGA cell cohorts, RNA activity of the Embryonic skeletal system development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2orf42, C7orf25, and PGK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic skeletal system development activity versus C2orf42 in LUNG_SCLC (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	C2orf42 →	-0.619	-0.283	.007	.005	3	4
LUNG_SCLC	C7orf25 →	-0.805	-0.248	.005	.002	3	4
OESOPHAGUS	PGK1 →	-0.886	-0.223	.007	.009	2	5
OESOPHAGUS	DHCR24 →	+1.645	+0.278	.006	.001	3	4
STOMACH	DFFB →	+0.647	+0.300	.003	.002	3	4
STOMACH	IL17D →	+1.258	+0.261	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048706 vs C2orf42 — LUNG_SCLC

Explore this scatter interactively →