Embryonic skeletal system morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic skeletal system morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN, RNF213, and DPYSL3_T509, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic skeletal system morphogenesis activity versus VCAN in OV (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VCAN →	+0.895	+0.034	.001	.001	3	7
HNSC	RNF213 →	-0.444	-0.043	<.001	<.001	3	7
LSCC	DPYSL3_T509 →	+0.743	+0.059	.001	<.001	3	7
OV	FKBP7 →	+0.496	+0.035	.001	<.001	3	7
HNSC	ARHGAP30 →	-0.666	-0.047	<.001	<.001	3	7
HNSC	DOCK8 →	-0.419	-0.036	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048704 vs VCAN — OV

Explore this scatter interactively →