Embryonic skeletal system morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic skeletal system morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX35, CCL13, and LILRA5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic skeletal system morphogenesis activity versus DHX35 in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DHX35 →	+0.625	+0.338	.001	.003	3	5
BRCA	CCL13 →	-1.641	-0.650	<.001	<.001	3	5
HNSC	LILRA5 →	-0.978	-0.316	<.001	.001	3	5
BRCA	SRGN →	-0.862	-0.613	<.001	<.001	3	5
BRCA	PTAFR →	-0.769	-0.638	<.001	<.001	3	5
BRCA	BRCA1P1 →	+1.116	+0.561	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048704 vs DHX35 — HNSC

Explore this scatter interactively →