Embryonic skeletal system morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic skeletal system morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FERMT2, UBE2M, and MRPL4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FERMT2 grouped by Embryonic skeletal system morphogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FERMT2 →	-1.994	-0.210	.002	<.001	3	4
LUNG_SCLC	UBE2M →	+0.897	+0.310	.006	.001	3	4
SKIN	MRPL4 →	+0.531	+0.288	.002	<.001	3	4
PANCREAS	AQP3 →	+4.792	+0.223	<.001	.004	3	4
LARGE_INTESTINE	CPT2 →	+0.862	+0.213	<.001	<.001	3	4
LARGE_INTESTINE	DTX3 →	-1.483	-0.149	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FERMT2 by Embryonic skeletal system morphogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →