Response to axon injury

Across TCGA cell cohorts, RNA activity of the Response to axon injury pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A18AS, COMT, and TMEM232, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC22A18AS grouped by Response to axon injury-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC22A18AS →	+0.431	+0.215	.005	.002	3	5
STOMACH	COMT →	+1.339	+0.391	<.001	.002	3	4
BREAST	TMEM232 →	-0.631	-0.191	.006	.007	3	4
LARGE_INTESTINE	PPP2R5C →	+0.572	+0.274	.001	.001	3	4
STOMACH	GPSM2 →	+0.858	+0.346	.001	.001	3	3
STOMACH	PPIB →	+0.986	+0.459	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC22A18AS by Response to axon injury activity — BLOOD_Leukemia

Explore this box plot interactively →