Response to axon injury

Across TCGA pan-cancer cohorts, RNA activity of the Response to axon injury pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 83 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Response to axon injury pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and ESCA, show the opposite pattern, with higher activity associated with better survival.

ACC, UVM, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Quartile	All	0.307	0.796	<.001	101	view →
UVM	DFS	Median	III,IV	0.305	0.678	.003	45	view →
SKCM	OS	Tertile	III,IV	0.845	0.501	<.001	40	view →
ESCA	DFS	Median	III,IV	0.582	0.235	.001	33	view →
UCS	OS	Quartile	II,III,IV	0.755	0.233	.012	30	view →
LIHC	OS	Median	All	0.433	0.591	.002	28	view →
STAD	DFS	Median	All	0.438	0.599	.008	23	view →
LUSC	DFS	Tertile	III,IV	0.168	0.850	<.001	18	view →
HNSC	DFS	Tertile	II,III,IV	0.415	0.293	.016	14	view →
READ	DFS	Quartile	III,IV	0.435	0.953	.001	11	view →
SCLC	OS	Tertile	All	0.827	0.598	.015	8	view →
OV	OS	Quartile	IV	0.266	0.633	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0048678–ACC (OS)

Open the ACC breakdown →