Response to axon injury

Across TCGA cell cohorts, RNA activity of the Response to axon injury pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPP6, STAT1, and COLGALT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MPP6 grouped by Response to axon injury-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MPP6 →	-0.133	-0.457	.003	.008	3	3
BLOOD_Leukemia	STAT1 →	+0.152	+0.993	<.001	.004	2	4
BONE	COLGALT2 →	-0.360	-0.266	.001	.002	3	3
BLOOD_Lymphoma	TNKS →	+0.430	+0.242	.001	.001	3	3
SKIN	IFIT3 →	-0.185	-1.054	.001	.005	3	3
BLOOD_Leukemia	MSANTD3-TMEFF1 →	-0.171	-1.166	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MPP6 by Response to axon injury activity — BREAST

Explore this box plot interactively →