Response to axon injury

Across TCGA cell cohorts, RNA activity of the Response to axon injury pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG12, KHDC1, and PTK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to axon injury activity versus ATG12 in OESOPHAGUS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ATG12 →	+1.189	+0.289	.006	.002	3	5
BLOOD_Leukemia	KHDC1 →	+1.092	+0.557	.003	.002	3	4
BLOOD_Lymphoma	PTK2 →	+2.431	+0.801	.005	.007	3	4
OESOPHAGUS	SLC6A6 →	+0.906	+0.219	.002	.002	3	4
BLOOD_Leukemia	UBE2NL →	-0.042	-0.516	<.001	<.001	3	3
OESOPHAGUS	YWHAZ →	+1.148	+0.372	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048678 vs ATG12 — OESOPHAGUS

Explore this scatter interactively →