Positive regulation of collateral sprouting

Across TCGA cell cohorts, RNA activity of the Positive regulation of collateral sprouting pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP26, GPT2, and SPIN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP26 grouped by Positive regulation of collateral sprouting-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ARHGAP26 →	+1.076	+0.765	.003	.003	3	4
STOMACH	GPT2 →	-1.464	-1.373	.007	.001	3	4
LUNG_NSCLC_LUSC	SPIN4 →	-1.400	-1.491	.001	.001	3	3
OVARY	DDB2 →	-1.200	-1.127	.005	.007	3	3
SKIN	FANCD2 →	-0.793	-1.401	.007	<.001	3	3
OVARY	ABHD15 →	-0.931	-1.724	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP26 by Positive regulation of collateral sprouting activity — BREAST

Explore this box plot interactively →