Collateral sprouting in absence of injury

pathway activity — cross-omics
GO:0048669Cross-omicsRNA → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Collateral sprouting in absence of injury pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPART, HIPK3, and CCDC169, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CHOLSPART →+1.488+0.094.002.001227
KIRPHIPK3 →+0.668+0.046<.001<.001317
PRADCCDC169 →+0.689+0.052<.001<.001317
MESOCOBL →+1.793+0.118<.001<.001316
ACCLMBRD2 →+1.011+0.086<.001.004217
THYMNFAT5 →+1.060+0.045<.001<.001316
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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