Neuron fate commitment

Across TCGA patient cohorts, RNA activity of the Neuron fate commitment pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HIC1, PTPRC, and CDC42EP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron fate commitment activity versus HIC1 in OV (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HIC1 →	+0.496	+0.042	.004	<.001	3	6
PDAC	PTPRC →	-0.415	-0.034	<.001	<.001	3	5
CCRCC	CDC42EP1 →	+0.342	+0.059	<.001	<.001	3	5
LSCC	FKBP7 →	+0.378	+0.038	.002	<.001	3	5
OV	HMCN1 →	+0.788	+0.038	<.001	<.001	3	5
GBM	MYO1G →	-0.556	-0.059	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048663 vs HIC1 — OV

Explore this scatter interactively →