Neuron fate commitment

Across TCGA patient cohorts, RNA activity of the Neuron fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF559, ZNF521, and HMCN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron fate commitment activity versus ZNF559 in LUAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZNF559 →	+0.320	+0.392	.005	.009	3	6
UCEC	ZNF521 →	+1.060	+0.368	.001	.006	3	5
LUAD	HMCN1 →	+0.618	+0.439	.001	.003	3	5
LSCC	FAM76A →	+0.270	+0.529	.002	.009	3	5
UCEC	PHC1 →	+0.387	+0.455	.005	.002	3	4
UCEC	CHD6 →	+0.609	+0.423	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048663 vs ZNF559 — LUAD

Explore this scatter interactively →