Negative regulation of smooth muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNRG, ZC3H12A, and GOT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of smooth muscle cell proliferation activity versus KCNRG in SOFT_TISSUE (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KCNRG →	+0.462	+0.407	.008	.004	2	6
BLOOD_Myeloma	ZC3H12A →	-2.179	-0.477	.007	.007	3	4
SKIN	GOT2 →	-0.399	-0.214	.007	.005	3	4
BREAST	VASH1 →	+1.442	+0.315	.003	<.001	3	4
STOMACH	SMC3 →	+1.463	+0.287	.009	.005	3	4
URINARY_TRACT	SLF2 →	+0.915	+0.365	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048662 vs KCNRG — SOFT_TISSUE

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