Positive regulation of smooth muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR4, TNFAIP3, and CD93, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smooth muscle cell proliferation activity versus TLR4 in SKCM (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TLR4 →	+1.500	+0.039	<.001	<.001	3	34
UCS	TNFAIP3 →	+1.691	+0.045	<.001	<.001	3	33
UCS	CD93 →	+1.521	+0.041	<.001	<.001	3	33
SKCM	FGL2 →	+2.105	+0.039	<.001	<.001	3	33
SCLC	GIMAP6 →	+1.565	+0.072	<.001	<.001	3	33
CHOL	THBS1 →	+2.442	+0.045	.001	.006	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048661 vs TLR4 — SKCM

Explore this scatter interactively →