Animal organ formation

Across TCGA patient cohorts, RNA activity of the Animal organ formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, CTSV, and CDCA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Animal organ formation activity versus TTK in BRCA (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTK →	-0.778	-0.636	.002	.002	3	4
BRCA	CTSV →	-0.594	-0.485	.007	.004	3	4
BRCA	CDCA5 →	-0.849	-0.776	.001	.001	3	4
BRCA	BUB1 →	-0.724	-0.593	.003	.004	3	4
BRCA	CHEK2 →	-0.454	-0.614	.004	.003	3	4
BRCA	FAM72B →	-0.557	-0.573	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048645 vs TTK — BRCA

Explore this scatter interactively →