Positive regulation of skeletal muscle tissue development

Across TCGA cell cohorts, RNA activity of the Positive regulation of skeletal muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM209B, NFIB, and ZNF506, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of skeletal muscle tissue development activity versus FAM209B in BLOOD_Leukemia (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM209B →	-0.256	-0.246	.004	.003	3	4
BLOOD_Lymphoma	NFIB →	+0.752	+0.286	.002	.002	3	3
BLOOD_Lymphoma	ZNF506 →	-1.065	-0.277	.001	<.001	3	3
BLOOD_Lymphoma	HPN →	-0.112	-0.297	.004	.009	3	2
BLOOD_Lymphoma	VIPR1 →	-0.340	-0.343	.008	<.001	3	2
BLOOD_Lymphoma	KCNE4 →	+0.046	+0.249	.003	.007	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048643 vs FAM209B — BLOOD_Leukemia

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