Negative regulation of muscle organ development

Across TCGA patient cohorts, RNA activity of the Negative regulation of muscle organ development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNORD115-43, OR2L1P, and TRBV30, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle organ development activity versus SNORD115-43 in GBM (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNORD115-43 →	-0.650	-0.542	.001	.001	3	3
GBM	OR2L1P →	+0.323	+0.563	.001	<.001	3	3
GBM	TRBV30 →	+0.302	+0.594	<.001	.002	3	3
PDAC	PRELID2 →	-0.460	-0.466	.002	.006	3	2
PDAC	LCN8 →	+0.044	+0.494	.006	.002	3	2
PDAC	MIR30C1 →	-0.535	-0.553	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048635 vs SNORD115-43 — GBM

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