Negative regulation of muscle organ development

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle organ development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSD17B7, CEP57, and PRKRA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSD17B7 grouped by Negative regulation of muscle organ development-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HSD17B7 →	-1.657	-0.621	.002	<.001	2	4
BLOOD_Lymphoma	CEP57 →	+1.054	+1.311	.002	.004	3	3
BLOOD_Lymphoma	PRKRA →	+0.623	+1.812	.005	<.001	2	4
BLOOD_Lymphoma	TTC3 →	+1.397	+1.852	.001	<.001	3	3
LUNG_NSCLC_LUSC	ADNP2 →	+1.175	+0.753	<.001	.004	3	3
LUNG_NSCLC_LUSC	LIAS →	+0.601	+0.407	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSD17B7 by Negative regulation of muscle organ development activity — BONE

Explore this box plot interactively →