Negative regulation of muscle organ development

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle organ development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CGB7, TCF4, and KLF6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle organ development activity versus CGB7 in LUNG_NSCLC_LUAD (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CGB7 →	+1.175	+0.412	.003	.008	2	4
CNS	TCF4 →	-1.276	-0.381	.002	.008	2	4
OESOPHAGUS	KLF6 →	+2.553	+0.471	.005	.009	3	2
OESOPHAGUS	MRPS33 →	+0.761	+0.430	<.001	.009	3	2
OESOPHAGUS	GARS1 →	+1.739	+0.590	<.001	.009	3	2
OESOPHAGUS	SBDS →	+2.040	+0.590	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048635 vs CGB7 — LUNG_NSCLC_LUAD

Explore this scatter interactively →