Regulation of muscle organ development

Across TCGA patient cohorts, RNA activity of the Regulation of muscle organ development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JPH2, EMBP1, and LZTS3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle organ development activity versus JPH2 in COAD (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	JPH2 →	+0.743	+0.566	.001	.001	3	4
LSCC	EMBP1 →	+0.487	+0.544	<.001	<.001	3	4
OV	LZTS3 →	-0.829	-0.641	.009	.003	3	3
UCEC	CLDN10 →	-1.911	-0.725	<.001	.002	3	3
UCEC	LYRM9 →	-0.284	-0.464	.007	.005	3	3
CCRCC	HNRNPA1P31 →	-0.213	-0.378	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048634 vs JPH2 — COAD

Explore this scatter interactively →