Regulation of skeletal muscle tissue growth

Across TCGA patient cohorts, RNA activity of the Regulation of skeletal muscle tissue growth pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIP2, LIPE-AS1, and TTC39A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle tissue growth activity versus CLIP2 in LSCC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLIP2 →	-0.560	-0.617	.005	.003	3	3
LSCC	LIPE-AS1 →	-0.289	-0.665	<.001	.008	3	3
CCRCC	TTC39A →	-0.744	-0.502	.002	.005	3	3
HNSC	HNRNPA1P34 →	+0.592	+0.741	<.001	<.001	3	3
UCEC	RNU6-158P →	+0.549	+0.969	.007	.001	3	3
HNSC	AGAP12P →	+0.671	+0.853	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048631 vs CLIP2 — LSCC

Explore this scatter interactively →